Wednesday 12th of May 2021

Follow Us

Breaking News

Swarnajayanti Fellow may provide new genetic treatment for thalassemia, duchenne muscular dystrophy, haemophilia

 (FM) - Duchenne Muscular Dystrophy, a severe type of muscle weakness that usually begins at an early age and worsens quickly, may soon have a new strategy of treatment through genetic regulation.

 

There is no known cure for duchenne muscular dystrophy. Treatments usually aim to control symptoms to improve quality of life.

 

Sandeep Eswarappa, Assistant Professor Indian Institute of Science (IISc), Bengaluru one of the 21 recipients of this year’s Swarnajayanti Fellowship of the Department of Science and Technology (DST), Government of India, proposes to suppress the disease-causing premature stop codon or the genetic process that initiates these diseases. He is trying to bring about the suppression through translational read through a gene regulatory principle found in humans, yeasts, bacteria and drosophila which takes place with the variation of the genetic code.

 

Prof. Sandeep’s group has been developing strategies to induce translational read through across genetic diseases caused by non-sense mutations -- a change in DNA that causes a protein to terminate or end its translation earlier than expected. They were successful in achieving this in vitro in case of thalassemia and are working on other disease models. This research work has been published in the scientific journal ‘Biochemistry’ recently. With the Swarna Jayanti fellowship, they will extend it to Duchenne muscular dystrophy. If successful, this project may lead to novel therapeutics for the treatment of genetic diseases like thalassemia, Duchenne muscular dystrophy, haemophilia.

 

 

 In case of any protein formation genetic information present in the genome is first transcribed into an mRNA, which in turn is translated into a protein. Protein synthesis or translation is executed by macromolecular machinery called ribosomes. Ribosomes start this process at a specific location on an mRNA called ‘start codon’ and terminate at a stop signal called ‘stop codon’. In case of diseases with nonsense mutations, such mutations result in premature stop signal in mRNA often resulting in non-functional truncated protein

 

Prof. Sandeep Eswarappa’s laboratory at IISc has shown that in certain mRNAs, under certain conditions, translating ribosomes misread the stop signal and continue till they encounter another stop signal. In this translational read through process, a longer protein is synthesized with an extension. This extension might change the properties of the protein. The experiments carried out by his group have revealed that such long proteins can have different localization, stability and function.

 

“The knowledge we have already gained from our experiment has opened up an unexpected avenue to treat genetic diseases caused by non-sense mutations like Duchenne muscular dystrophy, haemophilia and so on,” said Prof. Sandeep.

Related Sci & Tech News

Russia, Egypt preparing agreement on space cooperation - Roscosmos

 MOSCOW. March 5 (Interfax) - Roscosmos CEO Dmitry Rogozin and Egyptian Ambassador to Russia Ihab Nasr have discussed cooperation in the space exploration business, Roscosmos said.   "During a business conversation, the Russian and Egyptian sides discussed the current state and prosp....

India carries out successful user trials of DRDO-developed Anti-Tank Guided Missile Systems ‘Helina’ and ‘Dhruvastra’

 (FastMailNews) -Joint User Trials for Helina (Army Version) and Dhruvastra (Air Force Version) Missile Systemshave been carried out from Advanced Light Helicopter (ALH) platform in desert ranges. The missile systems have been designed and developed indigenously by Defence Research and Developm....

Science should be communicated in a manner that is inspirational, changes the mindset and attracts larger audience:Professor Ashutosh Sharma, Secretary, DST

 (Fast Mail News) -A programme has been initiated for engaging students, teachers, principals and leaderships of schools to develop scientific temper and foster a culture of continuous learning as well as to bring science and technology to the forefront.   “There are few programmes i....

Scientists find geological evidence of eastern Himalaya earthquake recorded in history

 (Fast Mail News) -Scientists have found the first geological evidence of an earthquake at Himebasti Village on the border of Assam and Arunachal Pradesh, documented by historians as Sadiya earthquake in history, which is recorded to have caused massive destruction in the region and almost dest....

WhatsApp postpones new private policy update

CALIFORNIA: WhatsApp postponed its new privacy policy update from Feb. 8 to May 15, the company announced Friday. The popular messaging app said in a statement that there is misinformation that is "causing concern” after users began switching to alternatives because its new privacy policy....

Links
Contact
Editor :
Jagadananda Pradhan
Email :
fastmailcc@gmail.com
news@fastmail.news
Ph : (+91)6764295999
Contact Us
© 2021 Fast Mail Media Pvt Ltd. All Rights Reserved.
Developed by : FM Media Pvt Ltd.